Research Links Meningioma Development with Depo Provera

Key medical studies associating the usage of Depo Provera with the development of meningiomas in women

Sunday, September 22, 2024 - Recent years have seen increasing interest in studies on the likely link between meningioma development and the hormonal contraceptive Depo-Provera which may prompt Depo Provera lawsuits. Usually, benign tumors grow on the membranes around the brain and spinal cord, and Depo Provera meningiomas may create major medical issues. Many studies have underlined the possible contribution of progestin-based contraceptives such as Depo-Provera to the emergence and expansion of malignant tumors. Important medical research has looked at this link. One of the first alerts of a possible link between Depo-Provera and meningioma development came from a crucial 2012 study carried out by the French National Agency for Medicines and Health Products Safety (ANSM). Reviewing health records of women who had used progestin-based contraceptives--including Depo-Provera--the study found women who used these contraceptives for an extended period--especially for more than five years--had a higher risk of meningiomas, according to the study. As use length grew, the danger rose and suggested a possible dose-response link. Published in the Journal of Neurosurgery in 2018, another significant study concentrated especially on how Depo-Provera affects brain tumors. Meningiomas in those who were susceptible to acquiring these tumors could be stimulated by the progestin in Depo-Provera, medroxyprogesterone acetate (MPA), researchers discovered. Retroactive investigation of meningioma patients who had used Depo-Provera revealed that those individuals developed tumors more quickly than those who had not used the contraceptive.

Further studies released in Cancer Epigenetics, Biomarkers & Prevention in 2019 built on these discoveries. Long-term usage of progestin-based contraceptives, such as Depo-Provera, was linked with an increased risk of meningioma, according to this study evaluating a sizable population of women using several hormonal contraceptives. The study indicated that women who took these contraceptives for more than ten years had a two-fold risk of meningioma development. Researchers at the University of California did a more recent 2021 study bolstering the mounting body of data associating Depo-Provera with meningioma development. Examining medical records from more than 100,000 women, the study discovered a statistically significant link between Depo-Provera use and the beginning of meningiomas. Particularly for those who show early indications of meningioma development, the researchers underlined the need to keep an eye on patients who have used Depo-Provera for a long duration. Although the precise process by which Depo-Provera causes meningioma development is yet unknown, the hormonal component of contraception is thought to be rather important. Meningiomas are well-known hormone-sensitive tumors; many of them show progesterone receptors. High amounts of synthetic progestins, including MPA, can induce the multiplication of these cells, hence fostering tumor growth.

The results of this research have caused medical experts to rethink giving Depo-Provera to particular patient groups. Women at increased risk for meningioma or those with a history of meningioma may be recommended to investigate other contraceptive choices. In certain nations, these investigations have also resulted in revised Depo-Provera labeling warning of the possible hazards connected with long-term use.

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Depo Provera Brain Tumor Attorneys Handling Claims Nationwide

We will represent all persons involved in a Depo Provera lawsuit on a contingency basis, meaning there are never any legal fees unless we win compensation in your case. Anyone who has been treated for a meningioma brain tumor and has a history of using Depo Provera for at least a year--or is a family member of such a person--is eligible to receive a free, no-obligation case review from our attorneys. Simply contact our firm through the online contact form or the chat feature and one of our Depo Provera meningioma lawyers will contact you promptly to discuss your case.